Friday, May 31, 2013

Wildfire sparked near power stations north of LA

SANTA CLARITA, Calif. (AP) ? A fast-growing wildfire was burning out of control Thursday night near power stations and utility lines north of Los Angeles and homes in a mountain community were being evacuated, officials said.

The fire in the Angeles National Forest surged to 1,000 acres after burning for about four hours, the U.S. Forest Service said, sending out big clouds of black smoke amid temperatures in the high 80s and winds gusting at more than 20 mph.

"The growth potential of this fire is great. It's burning medium to thick brush on steep slopes," said Sherry Rollman, a forest service spokeswoman.

The Los Angeles County Sheriff's Department was helping residents evacuate in the community of Green Valley. It was not clear how many homes are threatened, but about 1,000 people live in the area.

Both Southern California Edison and the Los Angeles Department of Water and Power said the fire was threatening their facilities and they were monitoring the blaze for potential outages, though none had been reported. Power was being rerouted away from the threatened lines.

The blaze broke out at about 3:30 p.m. Thursday, just north of Powerhouse No. 1, a hydroelectric plant near the LA aqueduct that was the first to bring municipal power to the city and has been operating for nearly a century.

One structure has burned but it was not immediately clear what it was.

Further north near Santa Barbara, a fire that burned nearly 2,000 acres in the Los Padres National Forest and forced the evacuation of thousands of campers when it broke out on Memorial Day was fully contained Thursday.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-05-30-California%20Wildfire/id-52425197e58b45da9b14158c688c4554

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In Vietnam, a Cuban rat poison finds new market

HANOI, Vietnam (AP) ? His wares banned in much of the world, the Vietnamese salesman hawking a rat poison laced with salmonella sought to prove the bait was as safe as claimed. He sliced open a packet with a pair of rusty scissors, dipped his finger into the sticky, bad-smelling rice, brought out a few grains and then chewed them gingerly.

"It tastes a little bitter, that's all," said Nong Minh Suu. He chose not to swallow the unhulled grains, instead spitting them out after a few seconds before lighting a cigarette. "When rats eat this, 100 percent of them will be killed. It is absolutely safe to human health."

Rat poisons normally come with warnings against human consumption and medical directions about what to do if accidentally eaten. Not so "Biorat," a bait produced in Vietnam by a Cuban-state owned company that earns foreign exchange for the Castro government.

The company claims the salmonella strain it includes is "harmless" to everything ? humans, the environment, pets and other animal species ? apart from rats. That is disputed by the Centers for Disease Control and Prevention, a U.S. federal government agency, and other international health institutions including the World Health Organization.

Biorat's production and sale in Vietnam is a legacy of the cozy ties between Cuba and Vietnam, two nations on opposite sides of the world but whose leaders are bound together by a public embrace of Communism. By operating here, the company, called Labiofam, can import ingredients free of any complications stemming from the U.S. trade embargo of Cuba that has been in force since the early 1960s.

It also gives it a base to try and enter new markets in Southeast Asia. The company is currently installing a new, automated production line at its Vietnam factory in preparation for a push in the region, where demand for rat poison is growing along with its population of rats, which nibble their way through at least 15 percent of the region's annual rice crop.

Labiofam produces an array of products alongside Biorat, from cancer treatments made from the stings of scorpions, larvacides that target mosquitoes, pesticides, even a probiotic range of yoghurt. They are marketed across the developing world, mostly in African and South American countries, where the company leverages government-to-government links forged in the Cold War and by the ongoing deployment of teams of Cuban health workers.

Salmonella, the name given to a group of bacteria, is the most common cause of food poisoning in the United States. In 2011, it was responsible for around 1 million illnesses and at least 29 deaths, according to the CDC. Most people infected with Salmonella develop diarrhea, fever, abdominal cramps, and vomiting. It is especially dangerous for young children and the elderly.

A strain of salmonella was used in rat poisons in Europe until the 1960s, but it was linked to several deaths and illnesses in humans, triggering the ban. Labiofam says it has isolated a different strain to that used in those preparations, but the CDC says its research shows it is the same. A 2004 report by the American agency even warned that it could be used in a bioterrorism attack.

"There are too many questions, why would you want to use something that has not been cleared by the CDC," said Grant Singleton, an expert on rodent biology and management at the International Rice Research Institute. "Its efficacy is questionable. I have not seen anything published in mainstream peer-reviewed scientific papers to demonstrate it's effective."

Singleton also pointed to an ingredient in the poison that its makers rarely mention: a small amount of warfarin, a chemical rodenticide in its own right, and suggested that it could be the agent that is killing rats. Company marketing literature refers to the chemical only as a "catalyst" though on the packet it is listed as warfarin.

The company said criticism of its product was a result of American hostility to the country and commercial jealousy. There are no documented deaths or illnesses as a result of using the product in Vietnam or other countries.

"It is quite complicated, but this all comes down to politics," said Gustavo Junco Matos, the head of the company in Vietnam, in an interview at a trade stand in Hanoi where the product was on display next to Cuba's better known exports: rum and cigars. "Ours is a biological product and only causes damages to rats."

The Vietnamese government, which controls all media in the country and doesn't allow for open discussion and criticism of its decisions, acknowledged that the product was banned in some countries, but said there was nothing to worry about. "We use it and find that it's effective and it's good in Vietnamese conditions," said Nguyen Xuan Hong, director of the plant protection department at the agriculture ministry.

Biorat's backers admit it has disadvantages: it is more expensive than most of its chemical competitors and needs to be refrigerated, adding to costs for distributors. But it has captured market share in several regions, something helped by government subsidies toward its purchase when it first hit the market 10 years ago, according to Suu.

There is so far little sign of Biorat getting much traction in Asian markets, even with the backing of the Cuban diplomats who are tasked with promoting it via its embassies in the region. Biorat demonstrations have been held in the Philippines and Indonesia, but so far its sales push has only resulted in one import license, that of Malaysia, according to the company.

Most of the 2,000 tones the factory and 100 workers produce each year is shipped to Angola, Biorat's number one market and a country that the Castro regime gave massive military, humanitarian and development support to from its 1960s independence struggle onwards. The company declined to reveal its global revenues.

At least one other Labiofam product has run into problems. The marketing of its larvacide as a major weapon in the battle against malaria in Africa has been criticized by international health organizations, which says larvacides have only a limited role to play.

"They do a very good job in getting governments to pay a lot of money for products that appear to be deficient," said Maria Werlau, a Cuban-American analyst from the U.S.-based Association for the Study of the Cuban Economy and a critic of President Raul Castro's government. "You don't have the same kind of accountability (in Cuba) that there is in other countries. There is no way to scrutinize what is going on. That's why they market these products in the developing world."

Rats have been feasting in Asia paddy fields since famers began cultivating it around 12,000 years ago, but an increase in the number of yearly harvests in many regions has meant more for them to feed on. As rat numbers increase, so does the economic cost: a loss of just 7 percent of Asia's rice crop is enough rice to feed 245 million people for 12 months.

Farmers in Vietnam often build plastic fences around their plots, which can protect them but only shifts the problem to neighbors. Trapping and electrocution, supposedly banned because of the risks posed to farmers of accidental electrocution, are common, but for many farmers poison is the weapon of choice, either routinely or when an infestation strikes.

Cao Thi Huong has been using Biorat for more than 10 years, spending around $30 on treating her small plot two times a year. She lives close to Suu's house, where boxes of Biorat are kept in large refrigerators at the back of the garden close to a chicken coop. "Personally speaking, I think it's better than the chemical," she said.

Source: http://news.yahoo.com/vietnam-cuban-rat-poison-finds-market-065102161.html

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Thursday, May 30, 2013

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Source: http://rss.msnbc.msn.com/id/38244200/device/rss/rss.xml

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This Guy Proposed to His Girlfriend with... Vine

This Guy Proposed to His Girlfriend with... Vine

I don't even... This is just... I can't believe... okay. Breathe. Some guy used Vine and Twitter to propose to his girlfriend. As in he recorded a six second Vine video (selfie?) asking her to marry him, with a ring and everything. She didn't say no.

She said yes! Curt Buthman's exact tweet was this:

Yes, there's two hashtags, an emoticon and a ridiculous Vine in one proposal tweet. One of those hashtags (#custserv) was actually being monitored by Buthamn's girlfriend Marsha Collier as she was holding a Twitter chat with it. When she ran into his tweet (and accompanying Vine), she was predictably stunned:

Proposing with memes, adorable. Proposing with drones, cool. Proposing with Vine? I'm just... love is love. We all have our own levels of what we're willing to share over social networks and we all have our own levels of obsession with social networks but something tells me that a Vine proposal wouldn't register as normal for umm... most of us. Sharing is usually done after the big question, I think. Different strokes and all that, I guess. But good luck to the happy couple! Maybe no Vines of the wedding night/birth of your children/and all the other stuff that's better between you two though. [Huffington Post]

Source: http://gizmodo.com/this-guy-proposed-to-his-girlfriend-with-vine-510394297

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Living in poor area as teen could increase risk for chlamydia in young adulthood

May 29, 2013 ? Living in a poor neighborhood as an adolescent is linked to an increased risk of getting the sexually transmitted infection (STI) chlamydia in young adulthood, according to new research.

Ohio State University researchers analyzed data from a large national study that tracked youths over time. The analysis suggested that children who lived in poor neighborhoods during their teenage years had an almost 25 percent greater risk of having chlamydia in their early 20s -- even if they themselves weren't poor -- than did teenagers living in wealthier settings.

The effect of living in an impoverished neighborhood on the risk for later infection was unaffected by other known STI risk factors, such as depression, having multiple sex partners or beginning sexual activity at a very young age.

"There is a long-term effect of living in poverty on the risk for sexually transmitted infections in young adulthood, above and beyond behavioral issues," said Jodi Ford, lead author of the study and an assistant professor of nursing at Ohio State. "We have a lot of interventions trying to address sexual risk behaviors, but few target neighborhood poverty and disadvantage. And this work shows that living in a poor neighborhood can have a long-term effect on health."

Ford conducted the research with Christopher Browning, professor of sociology at Ohio State. The study is published in a recent issue of the Journal of Urban Health.

Ford and Browning accessed data from the National Longitudinal Study of Adolescent Health (Add Health) to conduct the analysis. The sample they studied included data from three separate interviews of 11,460 youths who participated in the national project. When they were first interviewed, the average age of the children studied was 15.6 years; by the time of the third interview, these same participants were between 18 and 27 years old.

The prevalence of chlamydia among the young adults surveyed was 4.6 percent -- relatively low compared to what national data suggest, Ford said. That could be because the national longitudinal study from which she drew her sample took place in schools, meaning it did not capture portions of the population who had dropped out prior to the beginning of the Add Health study.

Chlamydia is a bacterial infection that can affect both men and women, but can cause scarring and infertility issues in women if the infection persists. An estimated 2.86 million infections occur annually, according to the Centers for Disease Control and Prevention, but many are not reported because most people do not have symptoms and do not seek testing.

"Adolescents and young adults are the most likely to experience chlamydia infection in the United States. This study strengthens the evidence that to fully address the sexual health needs of this population, STI prevention efforts should also acknowledge the effects of neighborhood poverty," Ford said.

The researchers considered four characteristics from U.S. Census data from corresponding years to determine whether the youths lived in poor neighborhoods as teenagers: proportion of households below poverty, proportion of households on public assistance, total unemployment rate and proportion of female-headed households with children.

By applying statistical modeling to the data, Ford determined that young adults who lived in a neighborhood with higher concentrations of poverty during their adolescence had higher odds of testing positive for chlamydia in their early 20s compared to their more advantaged peers.

The researchers also examined whether risky sexual behaviors or depression occurring during the transition from adolescence to young adulthood explained the relationship between adolescent poverty and chlamydia risk, but the findings were not significant. This means the significant effect of exposure to neighborhood poverty during adolescence on chlamydia risk during young adulthood was not because of an increased likelihood of sexual risk-taking behaviors or depression.

This analysis of data on a broad level does not address the reasons behind how living in an impoverished area can affect health later in life. The work is part of Ford's ongoing investigation of how neighborhoods can influence risk for depression, infectious disease and other health problems in vulnerable populations.

She continues to use data from the Add Health project, which was funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development.

This study was funded by a Robert Wood Johnson Foundation Nurse Faculty Scholar grant.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/aMC1oF89rYs/130529190733.htm

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Wednesday, May 29, 2013

Sonos enhances Spotify connections and more in new update

Sonos enhances Spotify connections and more in new updat

Sonos is already one of the most flexible music systems available, and with the latest 4.1 update to its controller software for iOS, OS X, Android and Windows, it's gotten even better.

Improvements include the ability to create playlists without using the queue - all you have to do is choose a track from any available source and add to your Sonos Playlist. You can edit playlists easier, too.

If you have a Spotify account, Sonos has some improvements there, too - you can create and edit Spotify playlists, and access and play music from Spotify playlist folders using your Sonos controller. You can also use Facebook or Spotify account credentials to link Spotify to Sonos.

New alarm options have been added and Sonos has improved component update speeds.

    


Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/0v7ezbpIDXM/story01.htm

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Charge your mobile phone with formic acid?

May 27, 2013 ? Surprisingly the answer is yes. With the technology of today it is possible to use environmental friendly formic acid in fuel cell powering your mobile phone or laptop. Physicist Florian Nitze, Ume? University in Sweden, has in his thesis developed new catalysts to improve the capacity of these fuel cells.

Fuel cells are different from batteries in that they require a constant source of fuel and oxygen to run. The technology is already commercially available but formic acid fuel cells still suffer from low power and lifetime.

The effect of a catalyst is to reduce the energy loss and to increase the rate of the chemical reactions, which leads to a higher efficiency in the fuel cell. In his thesis, Florian Nitze has developed new catalysts based on a combination of material science and nanotechnology -- engineering close to the atom level.

"Especially catalysts of palladium-nanoparticles attached to a unique helical formed carbon nanofibre proved to have a long lifetime and a very high potential to be used in formic acid fuel cells. The helical formed carbon nanofibre has a high electrical conductivity and a surface that is very easy to decorate with nanoparticles, "says Florian Nitze.

Several of the new catalysts that Florian Nitze have developed are based on palladium. It is a noble metal such as gold or platinum, but it is half as expensive.

Formic acid can be produced from renewable sources, i.e. wood, and is therefore a highly environmentally friendly alternative.

"One of the major advantages over Li-ion batteries, which are dominating the battery market, is that the charging only takes seconds by simple refueling with formic acid," says Florian Nitze.

Florian Nitze comes originally from Baden-Baden in Germany.

The working principle of a fuel cell: If for example hydrogen and oxygen (but equally valid for formic acid and oxygen) get in contact, they can burn and release a lot of energy. In this process hydrogen gives electrons to oxygen, it is oxidized whereas oxygen takes electrons from hydrogen, it is reduced.

The concept of a fuel cells is now to separate these two reaction spatially into two separate reactions, namely oxidation and reduction. The energy that would be released by burning can now be used as electric power if the two separated reactions are connected electrically. However, not all energy can be used; some energy is needed to keep the reaction running. Catalysts can lower this energy loss and speed up the reactions resulting in a higher efficiency of the fuel cell.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/strange_science/~3/og2UC6abToA/130527231802.htm

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Not Even 2, Girl With Arthritis Struggles to Walk

Campbell Pruden was only 19 months old, just beginning to talk, when she developed a limp and begged to be carried. The only way she could express her pain was to tell her parents, "It's too tight."

In 2011, the once energetic toddler was diagnosed and hospitalized with systemic juvenile idiopathic arthritis. At one point, she was taking eight daily medications. She was so afraid of the frequent steroid injections that she had to be put under anesthesia to keep her still enough for the procedure.

"In the beginning when there were all those unknowns, we knew we had to get to the bottom of it," said her mother, Kim Pruden, a 35-year-old speech pathologist from Phoenix.

"But at the same time, we had to keep that poker face with her to give her the confidence that, 'You are O.K. and you are going to be O.K.'"

The couple has their "breakdown" moments after Campbell goes to bed at night.

One of the greatest misunderstandings about arthritis is that it affects only adults. More than 300,000 children in the United States are living with the disease, according to the Arthritis Foundation, which has launched a new public awareness campaign to debunk the myths of arthritis during the month of May.

In addition to swelling in the joints, children can suffer muscle and soft tissue tightening and bone erosion that affect growth patterns.

Symptoms may include a non-contagious fever and rash. Inflammation can affect the spleen or the membranes that covering the lungs and heart.

It's important to recognize the symptoms of arthritis early, as many forms of arthritis can cause irreversible joint damage, often within the first two years of the disease. There are more than 100 types of arthritis and knowing what type you have makes a difference in how it is treated.

Today, at age 3, Campbell gets intravenous injections of powerful immune-suppressant medicines known as biologics, but office visits can last anywhere from two to five hours long. She calls the tiresome procedures her "stupid tubes."

Pruden laughs that the ordeal is like "going to Disney World for kids to get poked with needles."

Pruden and her husband John take a positive approach with their daughter whose joints are always aching.

"We keep her moving, we keep her active and we take one day at a time," she said. "When she is not feeling well, we respect that, but it's important not to make that a crutch or an excuse."

Arthritis is an umbrella term used to describe the many autoimmune and inflammatory conditions.

One family hard-hit by the disease recently moved from rainy Seattle to Charleston, S.C., for the warm climate, which is easier on the aching joints of sufferers.

Sisters Amelia, 5, and Liberty, 3, have juvenile idiopathic arthritis, which affects their joints "from head to toe," according to their mother, Lisa Schultz, who was recently diagnosed with rheumatoid arthritis.

Their father has had gout since he was 20, which is also a form of arthritis.

Amelia was diagnosed in April 2010 when she was nearly 2. She suddenly stopped walking and reverted to crawling.

"She started limping in the morning and wanted to be carried," said Schultz, 37 and a stay-at-home mother. "She would cry when I changed her diaper, too. I would lift her up and she would say her toes hurt when I put on her socks. Her second toe was almost the size of her big toe and her knees were the size of oranges."

Source: http://abcnews.go.com/Health/toddlers-struggle-juvenile-arthritis-disease-people/story?id=19250859

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Holiday Builders ? The Right Choice for Your New Home

Holiday Builders New Home Builder in FL,AL, SC, TX : Holiday Builders ? The Right Choice for Your New Home

Holiday Builders ? The Right Choice for Your New Home


Holiday Builders is proud to have achieved a reputation as the builder of best priced, quality new homes of lasting value. With distinctive community locations throughout Florida, Texas, and South Carolina, Holiday Builders offers their new home buyers a wide array of home styles to choose from. Holiday Builders home designs showcase the latest in architectural design trends and offer numerous floor plan options which are light filled and spacious ? perfect for modern family living as well as entertaining. Select the Holiday home design most suited to you and personalize it with the premium custom details which will make it uniquely your own.?
Holiday Builders communities are designed to give you access to every modern convenience. From the numerous on-site amenities each community features, to the ease of access to nearby schools, medical facilities, shopping and dining, and employment opportunities ? every Holiday community is focused on providing you and your family easy living and quality lifestyle. It?s easy to see why more than 35,000 families and counting have chosen Holiday to turn their new home dreams into reality. Now it is your turn - are you ready to Live Holiday Style? Call today to speak with a Customer Representative and learn more or stop by and tour one of Holiday Builders stunning model homes today.

Source: http://myholidaybuilders.blogspot.com/2013/05/holiday-builders-right-choice-for-your.html

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Preterm birth affects ability to solve complex cognitive tasks: Too early to learn

May 27, 2013 ? Being born preterm goes hand in hand with an increased risk for neuro-cognitive deficits. Psychologists from the Ruhr-Universit?t Bochum and the University of Warwick, UK have investigated the relation between the duration of pregnancy and cognitive abilities under varying work load conditions.

"Cognitive performance deficits of children dramatically increase as cognitive workload of tasks increases and pregnancy duration decreases," says Dr Julia J?kel from the Ruhr-Universit?t. In the journal PLOS ONE, the researchers report a new cognitive workload model describing the association between task complexity and incremental performance deficits of preterm children.

Large numbers of preterm born babies will place new demands on education system

About 15 million, i.e., more than ten per cent of all babies worldwide are born preterm every year; that is before the 37th week of pregnancy -- and the numbers are rising due to improvements in neonatal medicine and demographic changes. Recent studies suggest that delivery at any gestation other than full term (39 to 41 weeks gestational age) may impair brain development, rendering survivors at risk for adverse neuro-cognitive outcomes. Considering that 50 per cent of children are born before the 39th week of pregnancy, even small increases in cognitive impairments may have large effects on a population level. "As the total number of children born preterm increases there will be parallel increases in special education needs placing new demands on the education system," Julia J?kel and her colleagues say. To date, uncertainties remain regarding the nature and underlying causes of learning difficulties in preterm children. The new cognitive workload model now reconciles previous inconsistent findings on the relationship of gestational age and cognitive performance.

Cognitive deficits of children born preterm depend on the workload of the task

The research team tested 1326 children, born between weeks 23 and 41 of pregnancy, at an age of eight years. Data were collected as part of the prospective Bavarian Longitudinal Study. The children took part in a range of cognitive tests with varying workload. High workload tasks require the simultaneous integration of different sources of information, thereby placing high demands on the so called working memory. The results: The higher the workload and the shorter the pregnancy duration, the larger were the cognitive performance deficits. Deficits were disproportionally higher for children born before the 34th week of pregnancy compared with children born after week 33. Being born preterm specifically affected the ability to solve high workload tasks, whereas lower workload tasks were largely unaffected.

Results are relevant for cognitive follow-ups and planning of school lessons

According to the researchers, these results should be taken into account for routine cognitive follow-ups of preterm children as well as for planning school lessons. "New studies suggest that computerized training can improve working memory capacity," Prof Dieter Wolke from Warwick says. "In addition, educational interventions could be developed in which information is not presented simultaneously to preterm children but more slowly and sequentially to promote academic attainment."

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/iI8vxEmyf0A/130527100434.htm

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Tuesday, May 28, 2013

Home prices accelerate by most in seven years

By Leah Schnurr

NEW YORK (Reuters) - Home prices accelerated by the most in nearly seven years in March as the spring buying season gave the sector traction, while surging consumer confidence pointed to some resilience for the economic recovery.

The data on Tuesday also suggested the two segments could act as buffers as the broader economy faces the pinch of belt-tightening in Washington.

The S&P/Case Shiller composite index of 20 metropolitan areas climbed 10.9 percent year over year, beating expectations for 10.2 percent. This was the biggest increase since April 2006, just before prices peaked in the summer of that year.

Prices in the 20 cities gained 1.1 percent in March compared to the month before on a seasonally adjusted basis, topping economists' forecasts for a 1 percent rise.

The housing market turned a corner in 2012, several years after its far-reaching collapse. The recovery has picked up since as inventory has tightened, foreclosures eased and historically low mortgage rates have attracted buyers.

A Reuters poll showed the recovery in the housing market likely has momentum through the rest of the year, with economists ratcheting up their forecasts for price gains in 2013.

Separate data showed consumer confidence picked up in May to its highest in more than five years in the midst of a stock market rally and lower gasoline prices.

Housing and the consumer have shown strength even as there have been hints that tighter fiscal policy is starting to bite in the broader economy. Across-the-board U.S. government spending cuts of $85 billion went into effect in March, while the payroll tax holiday expired at the beginning of the year, raising taxes for many Americans.

The data suggested both areas were performing better than the overall economy, said Sam Bullard, senior economist at Wells Fargo in Charlotte, North Carolina.

"There are some individual circumstances that are helping to propel both of these a little bit stronger than what the actual underlying strength would suggest," said Bullard, pointing to the effect of higher stock prices on consumers, and investor demand for homes in beaten-down regions lifting prices.

Economists expect the pace of growth likely cooled in the second quarter, partly due to tighter fiscal policy, but the second half of the year is seen regaining traction. Investor attention has turned to when the Federal Reserve might start to slow its economic stimulus efforts.

The data lent support to equities where Wall Street rose after comments from central banks around the world reassured investors supportive monetary policies would remain in place. U.S. Treasuries yields rose to their highest levels in over a year.

Housing-related shares rose following the Case-Shiller report before giving up some gains in the afternoon, with the S&P homebuilders ETF up 0.4 percent. The ETF is up nearly 20 percent for the year, outpacing the more than 16 percent surge seen in the benchmark S&P 500 index.

Home prices in Phoenix continued their sharp ascent, rising 22.5 percent from a year earlier. Other standouts included San Francisco, up 22.2 percent, and hard-hit Las Vegas, up 20.6 percent.

Fitch Ratings on Tuesday said the recent home price gains seen in several markets are outpacing improvements in the underlying fundamentals and could stall or even reverse. Many of these areas are in California, Fitch said, citing Los Angeles as an example.

Los Angeles prices rose 16.6 percent from a year ago, the Case-Shiller report said.

For the first quarter of this year, the seasonally adjusted national index rose 3.9 percent, stronger than the 2.4 percent gain seen in the final quarter of last year.

"Low inventories and gradually improving housing demand have combined to push housing starts higher and support home price appreciation," said Michael Gapen, an economist at Barclays in New York.

"We see these factors as remaining in place and expect residential investment to add to GDP growth in the coming quarters. We also expect rising real estate wealth to support household balance sheets and underpin consumption, helping the broader economy to offset a substantial fiscal drag in 2013."

The Conference Board, an industry group, said its index of consumer attitudes jumped to 76.2 from an upwardly revised 69 in April, topping economists' expectations for 71. It was the best level since February 2008.

In a sign of confidence among high-end consumers, jeweler Tiffany & Co reported better-than-expected sales for the first quarter.

Consumer activity accounts for about two-thirds of the economy and while improved sentiment does not necessarily translate into more spending, the improvement was encouraging.

Still, even with the gain in confidence in May, second-quarter consumption growth is likely to have slowed to a 2.5 percent annualized pace from 3.2 percent in the first quarter, according to Capital Economics.

The expectations index rose to 82.4 from 74.3, while the present situation index climbed to 66.7 from 61.

Consumers' assessment of the labor market improved. The "jobs hard to get" index slipped to 36.1 percent from 36.9 percent the month before, while the "jobs plentiful" index gained to 10.8 percent from 9.7 percent.

(Editing by Chizu Nomiyama)

Source: http://news.yahoo.com/home-prices-accelerate-most-seven-years-004137517.html

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Obama visits Oklahoma town digging out after tornado

By Jeff Mason

MOORE, Oklahoma (Reuters) - President Barack Obama arrived in Moore, Oklahoma, on Sunday to tour the town that was hammered last week by a powerful tornado that killed 24 people and assure its residents that the federal government would provide long-term help.

His first stop was Plaza Towers Elementary School, where seven children died and several students and teachers were injured by the May 20 afternoon storm.

Piles of boards, brick and cinder blocks that used to be buildings and houses lined the side of the street. Rare items that survived the disaster - a television set, a pink baby carriage - stood in contrast to the wreckage.

Cars with their bodies dented and windows smashed lay under debris or twisted on their sides. Rising above the wasteland were at least three American flags that had been attached to the rubble, waving in the wind.

"The president's message is that support is not winding down," White House spokesman Josh Earnest told reporters on Air Force One. "As demonstrated by our efforts in Tuscaloosa, in Joplin, and those communities in Connecticut, New York, and New Jersey that were affected by Sandy, we'll be standing with the people of these resilient communities as they come back stronger than ever."

Obama has been repeatedly called on in recent months to comfort shaken U.S. communities, from a visit last month to Boston in the wake of the marathon bombings, to Newtown, Connecticut, the site of a December mass school shooting.

Tuscaloosa, Alabama, and Joplin, Missouri, were hard-hit by tornadoes two years ago.

The Moore tornado, which rated the most powerful on the five-step scale used to measure the destructive power of twisters, ripped a 17-mile (27-km) long corridor of destruction through the suburb of Oklahoma City, flattening entire blocks of homes, two schools and a hospital in some 50 minutes on May 20.

It was the most powerful of a spate of 76 twisters that touched down in 10 states from May 18 through 20, causing an estimated $2 billion to $5 billion in insured losses, according to disaster modeling company Eqecat.

Some 377 people were injured by the Moore tornado, the deadliest such windstorm to hit the United States in two years.

(Additional reporting by Heide Brandes; Writing by Scott Malone; Editing by Sandra Maler)

Source: http://news.yahoo.com/obama-visit-tornado-oklahoma-town-sunday-143110804.html

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EU should be willing to amend arms embargo on Syria: Hague

By Andrea Shalal-Esa WASHINGTON (Reuters) - Depending on your point of view, U.S. General Keith Alexander is either an Army four-star trying to stave off a cyber Pearl Harbor attack, or an overreaching spy chief who wants to eavesdrop on the private emails of every American. Alexander, 61, has headed the National Security Agency since 2005, making him the longest-serving chief in the history of an intelligence unit so secretive that it was dubbed "No Such Agency." Alexander also runs U.S. ...

Source: http://news.yahoo.com/eu-willing-amend-arms-embargo-syria-hague-091141854.html

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Chevron targets Australia LNG expansion despite cost pressure

BRISBANE (Reuters) - Chevron Corp's $52 billion Gorgon liquefied natural gas (LNG) development in Australia is now 60 percent complete and plans are afoot to start engineering and design work for an expansion by the end of the year, a company executive said.

Chevron also continues to talk with third-party gas suppliers for a potential expansion of its $29 billion Wheatstone LNG plant, Roy Krzywosinski, managing director of Chevron Australia, told reporters at an industry conference in Brisbane on Tuesday.

The Wheatstone plant in Australia is about 10 percent complete, he said.

The U.S. company's plans to continue pursuing LNG capacity expansion come amid concerns that Australia's high cost structure will discourage further investment in the $190 billion LNG industry.

Woodside Petroleum last month shelved plans for its $45 billion Browse LNG project in Western Australia, saying it will consider a floating LNG plant after deciding the onshore development did not make economic sense.

Gorgon, which will have a capacity of 15.6 million tons of LNG per year, is currently on schedule to ship its first LNG cargo in early 2015. The expansion is expected to add another 5.2 million tons a year.

Chevron is building a plant with a capacity of 8.9 million tons at Wheatstone, but the site has government approval to grow to a 25 million-ton hub. Wheatstone is scheduled to ship its first cargo out in 2016.

Krzywosinski, however, warned that Australia's high costs could impact the company's investment decisions going forward.

"Nothing is a slam dunk... the issue of cost structure is a significant issue, especially if you have an international portfolio of competing priorities," he said.

"You're not going to dump more money into an existing investment if you have a better alternative."

Gorgon LNG, which has seen a 40 percent cost hike, has about 65 percent of its LNG sold under long-term contracts, short of the 80 to 90 percent that LNG producers typically aim to have sold under long-term contracts.

"The closer we get to first LNG, the more valuable the volumes are going to be, so we're confident that we'll be able to market those incremental volumes," Krzywosinski said.

(Reporting by Rebekah Kebede; Editing by Muralikumar Anantharaman)

Source: http://news.yahoo.com/chevron-targets-australia-lng-expansion-despite-cost-pressure-040156554.html

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Friday, May 24, 2013

Russia: Syrian regime may take part in peace talks

In this image from amateur video obtained by a group which calls itself Ugarit News, a rebel runs from an explosion, Sunday, May 19, 2013, in Qusair, Syria. The video is consistent with independent AP reporting. Hezbollah was pulled more deeply into Syria's civil war as 28 guerrillas from the Lebanese Shiite militant group were killed and dozens more wounded while fighting rebels, Syria activists said Monday. The intense battle drove rebels from large parts of Qusair, part of a withering government offensive aimed at securing a strategic land corridor from Damascus to the Mediterranean coast. (AP Photo)

In this image from amateur video obtained by a group which calls itself Ugarit News, a rebel runs from an explosion, Sunday, May 19, 2013, in Qusair, Syria. The video is consistent with independent AP reporting. Hezbollah was pulled more deeply into Syria's civil war as 28 guerrillas from the Lebanese Shiite militant group were killed and dozens more wounded while fighting rebels, Syria activists said Monday. The intense battle drove rebels from large parts of Qusair, part of a withering government offensive aimed at securing a strategic land corridor from Damascus to the Mediterranean coast. (AP Photo)

(AP) ? The Syrian government has agreed "in principle" to attend a conference proposed by Russia and the United States on ending the Arab country's conflict, Russia's foreign ministry said Friday.

It was the first confirmation that President Bashar Assad's government would be willing to take part in the talks with the opposition.

But despite the announcement from Moscow, one of Assad's staunchest allies, Damascus has not offered any definitive statement on the proposed talks.

Russia and the U.S. joined efforts earlier this month to convene an international conference to bring representatives of Assad's regime and the opposition to the negotiating table. The aim of the talks would be to establish the outlines of a transitional government as a way out of the crisis.

More than 70,000 people have been killed and several million displaced since the uprising against Assad erupted in March 2011 and escalated into a civil war.

The U.S.-Russian plan, similar to the one set out last year in Geneva, calls for talks on a transitional government and an open-ended cease-fire.

The Moscow announcement came after days of talks there between Syria's Deputy Foreign Minister Faysal Mekdad and Russian officials.

Russia's Foreign Ministry spokesman Alexander Lukashevich said in televised remarks Friday that the Syrian government has "agreed in principle" to participate in the conference in Geneva, which is expected within two weeks.

"We note with satisfaction that we have received an agreement in principle from the Syrian government in Damascus to participate in the international conference, in the interest of Syrians themselves, to find a political solution," Lukashevich said.

He added, however, that it is impossible to set the date for the conference at this point because there is "no clarity about who will speak on behalf of the opposition and what powers they will have."

Lukashevich also said Moscow "was not encouraged" by the results of recent meetings of members of the Syrian National Coalition, the country's main opposition group that has called on Assad to step down.

In Turkey, where the Syrian National Coalition is holding a three-day conference, an opposition figure expressed doubts over Moscow's announcement, questioning why Damascus has said nothing on the subject.

"We are very supportive of the (U.S.-Russian) initiative. Our fear is that the regime is not going to negotiate in good faith. We would like to hear enough (from Damascus) to know that they are serious about these negotiations," said Louay Safi, a member of the opposition coalition.

The U.S., along with key European and Arab supporters of Syria's opposition, said on Wednesday that Assad must relinquish power at the start of a transition period. Russia, however, has not committed to Assad's departure and the Syrian leader has said he will not step down before his term ends next year.

U.S. Secretary of State John Kerry on Thursday acknowledged the difficulties of launching peace talks. "Nobody has any illusions about how difficult, complicated, what a steep climb that is," he said during a visit to Israel.

Fighting continued across Syria on Friday, and state media reported that rebels fired mortar shells at the central prison in the embattled northern city of Aleppo, killing and wounding several inmates.

The pro-opposition Aleppo Media Center said clashes were underway between rebels and government troops at the prison and that a large fire had broken out at the facility.

The fighting came a week after Assad's forces repelled a rebel raid on the prison that sought to free hundreds of political prisoners.

The Britain-based Syrian Observatory for Human Rights said intense fighting was also continuing in the western Syrian town of Qusair, near the border with Lebanon.

Government forces have been trying to recapture the town since Sunday. State-run news agency SANA said troops killed a "large number" of rebels in the latest clashes.

____

Associated Press writers Nataliya Vasilyeva in Moscow and Ayse Wieting in Istanbul contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-05-24-Syria/id-fedd7d949c064f978f63ba1ed2c135ed

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Journalist and author Haynes Johnson dies at 81

(AP) ? Haynes Johnson, a pioneering Washington journalist who won a Pulitzer Prize for his coverage of the civil rights movements and migrated from newspapers to television, books and teaching, died Friday. He was 81.

The Washington Post reported he died at Suburban Hospital in Bethesda, Md. In a statement to the Post newsroom, Managing Editor Kevin Merida said Johnson died of a heart attack.

Johnson was awarded a Pulitzer in 1966 for reporting on the civil rights struggle in Selma, Ala., while with the Washington Evening Star. He spent about 12 years at the Star before joining its chief rival, The Washington Post, in 1969. Johnson was a columnist for the Post from 1977 to 1994.

Dan Balz, the Post's senior political reporter, said Johnson was already a legend before they got to work together at the newspaper.

"I don't say this lightly. He was a great journalist," Balz said Friday. "He had everything a good reporter should have, which was a love of going to find the story, a commitment to thorough reporting and then kind of an understanding of history and the importance of giving every story kind of the broadest possible sweep and context."

Former Post executive editor Leonard Downie told the newspaper, "Haynes was a pioneer in looking at the mood of the country to understand a political race. Haynes was going around the country talking to people, doing portraits and finding out what was on people's minds. He was a kind of profiler of the country."

The author, co-author or editor of 18 books, Johnson also appeared regularly on the PBS programs "Washington Week in Review" and "The NewsHour." He was a member of the "NewsHour" historians panel from 1994 to 2004.

"I knew I wanted to write about America, our times, both in journalism and I also wanted to do books," he told C-SPAN in 1991. "I wanted to try to see if I could combine what I do as a newspaper person as well as step back a little bit and write about American life, and I was lucky enough to be able to do that."

Johnson had taught at the University of Maryland since 1998.

"Hundreds of our students learned how to cover public affairs from one of the best journalists America has ever known," Merrill College Dean Lucy Dalglish said in a written statement released by the university. "It was equally obvious to anyone who looked through the window that Haynes was in his element in the classroom. His entire face lit up when he was in the middle of a classroom discussion."

Johnson had attended graduation ceremonies on Monday for the university's journalism college.

Kathryn Oberly, Johnson's wife, told the school's Capital News Service that Johnson entered the hospital earlier this week for heart tests and died Friday morning of a heart attack.

Johnson also had teaching stints at George Washington University, Princeton University, the University of California, Berkeley, and the University of Pennsylvania.

He was born in New York City on July 9, 1931. His mother, Emmie, was a pianist and his father, Malcolm Johnson, a newspaperman. The elder Johnson won a Pulitzer Prize for the New York Sun in 1949 for his reporting on the city's dockyards, and his series suggested the story told in the Oscar-winning film "On the Waterfront."

Johnson studied journalism and history at the University of Missouri, graduating in 1952. After serving three years in the Army during the Korean War, he earned a master's degree in American history from the University of Wisconsin in 1956.

Johnson resisted working in New York journalism to avoid being compared to his father. He worked for nearly a year at the Wilmington (Del.) News-Journal before joining the Star as a reporter.

When Ben Bradlee became the editor of the Post, he began beefing up the paper's political reporting team, recruiting both Johnson and David S. Broder to join the paper.

"He reached out, held out his hand, and I grabbed it, and that was it," Johnson recalled in Jeff Himmelman's 2012 biography of Bradlee. "There was no contract, nothing. It was just, 'Come, we want you,' and I've never forgotten that."

Johnson's books include "The Battle for America 2008: The Story of an Extraordinary Election," (2009) with Balz; "The Best of Times: America in the Clinton Years" (2001); and "The System: The American Way of Politics at the Breaking Point" (1996) with Broder.

Johnson and Broder helped redefine Washington reporting, getting outside the Beltway to talk with voters about candidates and issues, rather than letting politicians dictate daily coverage. Both then wove that reporting into broader articles that examined the political process, the workings of government and the mood of the country.

"Hayes was a giant," journalism professor and author Carl Sessions Stepp commented on the University of Maryland's website. "He had the mind of a scholar and the soul of a regular citizen, and nobody has ever better combined insider digging and outside-the-Beltway pulse-taking."

Gene Roberts, who helped lead The Philadelphia Inquirer and The New York Times, said he was amazed with Johnson's work ethic.

"I think he was one of the most important reporters in the country during his journalistic career and later as he got more into books," Roberts said. "I was amazed. Most writers take a breather between books, but when he finished one book he always started immediately on another book."

Johnson and Roberts taught together at the University of Maryland. Roberts said Johnson was an inspirational teacher and a serious historian. In recent years, he said, Johnson had been focused on having his father's "Waterfront" articles printed in book form.

He had just begun work on a 19th book, looking at the speed with which breaking news was covered in the social media era, according to Capital News Service.

Johnson married Julia Ann Erwin in 1954; they had three daughters and two sons and later divorced. In 2002, Johnson married Kathryn Oberly, an associate judge on the District of Columbia Court of Appeals.

___

Zongker contributed from Washington.

___

EDITOR'S NOTE: Barry Schweid reported on foreign policy, the Supreme Court and national politics for The Associated Press in Washington for more than 50 years.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2013-05-24-AP-US-Obit-Haynes-Johnson/id-8626f04472364e2eacebe0214fd8aa4a

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2014 Chevy Spark EV will retail for $27,495 before incentives, hits West Coast freeways in mid-June

Chevy just announced pricing for its 2014 Spark EV. The all-electric compact will retail for $27,495 before incentives, such as a $7,500 federal tax credit and up to $2,500 in state and local credits. All told, you could drive the car home for less than 18 grand, and California residents will net HOV (carpool lane) access to boot. The two-door vehicle ships with a 21kWh battery pack, giving you an estimated range of 82 miles on a full charge. You can also add on DC Fast Charging capability, letting you recharge up to 80 percent in about 20 minutes at select stations. Alternatively, you can charge up using a 240-volt system in about seven hours. The car also includes Chevy's MyLink infotainment platform, the RemoteLink smartphone app and three years of OnStar service. It'll be available at select dealers in California and Oregon by mid-June.

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In first public acknowledgement, Holder says 4 Americans died in US drone strikes

Chip Somodevilla / Getty Images file

Attorney General Eric Holder testifies before the Senate Judiciary Committee on March 6.

By Michael IsikoffNational Investigative Correspondent, NBC News

The Obama administration publicly acknowledged for the first time Wednesday that U.S. drone strikes have killed four American citizens since 2009, including the previously undisclosed death of a North Carolina resident who left the United States for Pakistan and was later indicted on federal terrorism charges.

Attorney General Eric Holder, in a letter to congressional leaders and chairman of key congressional committees made public on the eve of what was billed as a major counterterrorism speech by President Barack Obama, also confirmed the deaths in drone attacks in Yemen of three other Americans that already had been widely reported: those of radical cleric Anwar Al-Awlaki , his teenage son, Abd al-Rahmn Anwar al-Awlaki; and Samir Khan, the American who ran al Qaeda?s web-based propaganda magazine Inspire.? Previously the Obama administration had only acknowledged the senior Awlaki?s killing and refused to publicly confirm or deny reports of the other deaths.

The letter also confirmed that U.S. drones had killed Jude Kenan Mohammed of Raleigh, N.C., more than a? year after a local news report quoted a friend as saying he had died in an attack in Pakistan in November 2011.

Holder said in the letter that the senior Awlaki was the only U.S. citizen targeted in a drone strike.

Anonymous / AP

Anwar al-Awlaki, a U.S.-born Yemeni cleric and recruiter for al Qaeda in the Arabian Peninsula in Yemen, is shown in an October 2008 file photo.

He also provided new details about what the U.S. says were Awlaki's operational roles in terror plots, including his role in a 2010 attempt to bomb cargo planes by putting bombs in printer cartridges.

It also included an explicit explanation of the U.S. policy for targeted killings of Americans, much of which was included in a ?white paper? obtained by NBC News in February.

Mohammed?s death appears to have been news to the FBI, which as of Thursday still listed him on its ?most wanted? list, saying, ?On July 22, 2009, a federal grand jury in North Carolina indicted Jude Kenan Mohammad for conspiracy to provide material support to terrorists and conspiracy to murder, kidnap, maim, and injure persons in a foreign country. Mohammad is at large ? (and) is believed to be in Pakistan.?

A law enforcement official who spoke on condition of anonymity told NBC News: ?We don?t know when he was killed. That fact was classified.?

FBI spokeswoman Shelley Lynch said in an email: "Jude Kenan Mohammed remained wanted until there was official confirmation of death.? Until now, the matter was classified and it is now appropriate for the wanted poster to be removed from our website."?

Obama is expected to discuss the drone program Thursday in a speech at the National Defense University in Washington, D.C.

Release of Holder?s letter came as classified documents obtained by NBC News raised new questions about the CIA-run drone program and whether it is consistent with public comments by Obama and other administration officials describing? the strikes as ?very precise? and targeted at specific al Qaeda operatives and their associates. In fact, the documents show, the agency has frequently attacked low-level militants and foreign fighters in Pakistan whose names and nationalities were not known, as well as militant groups not directly connected to al Qaeda.

The documents, similar to those recently reported by McClatchy Newspapers,?offer a window into the secretive drone program and how its actual operations sometimes differ from the public accounts provided by the administration.

They appear to officially confirm that the agency has engaged in ?signature strikes? ? a much discussed and controversial practice that has never been publicly acknowledged -- in which CIA drone operators target individuals based on the ?signature characteristics? of suspects but whose actual identities are not clear.

They surface at a time that U.S officials appear to be scaling back the drone program ? amid warnings from some? former military and intelligence officials that the attacks may be creating a backlash harmful to U.S. interests in the long run.

?When Obama was asked about the drone program last year during a Google News forum, he called it ?a targeted, focused effort at people who are on a list of active terrorists.? In an April 2012 speech, then White House counter-terrorism adviser and now CIA Director John Brennan said: ?The United States Government conducts targeted strikes against specific al Qaeda terrorists,? while acknowledging that drone targets included ?associated forces.?

But a CIA list of 53 drone strikes in the fall of 2010 indicates that fewer than half ? 22 -- listed al Qaeda operatives as the targets. Other strikes were aimed at targets that included suspected members of the militant al-Haqqani network in Pakistan, which is believed to have harbored and worked with al Qaeda; members of the Pakistani Taliban, an Islamic fundamentalist military group that aims to overthrow the Pakistani government; and members of another Pakistani terrorist network identified as the ?Commander Nazir Group.?? Fourteen of the strikes listed the targets only as ?other militants.?

Agency lists for other periods show a higher proportion of strikes being specifically aimed at Al Qaeda operatives. For example, during a nine month period between January and September 2011, 28 out of 42 strikes listed al Qaeda members as targets.

But in other accounts of the strikes, agency officials refer to the targeting of individuals whose identifies do not appear to be known. One 2009 attack was described as being aimed at ?military aged males?? at a site ?associated with al Qaeda explosives training.? Another, in 2010, described the target as ?four adult males conducting weapons training.?

The CIA and White House did not respond to requests for comment about the documents. But U.S. officials have vigorously defended the drone program and their public accounts of it, while saying they are limited in what they can say because of its classified nature and the potential impacts of full public disclosure in Pakistan.?As for the use of signature strikes , they have argued that ?when you have a bunch of guys building explosives, you don?t need to know who they are. They are an imminent threat.?

NBC News? Pete Williams, Chuck Todd and Tom Curry contributed to this report.

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Myths About College

? I am not a mental health professional and this is not an advice blog. However, I'm more than happy to share with you my experiences as a psychology student.
? The materials on this blog unless otherwise sourced or reblogged are created by me. You are free to reblog or share my material, but if you reupload them please credit me or the original creator.
?The facts on this blog are subjected to personal evaluation. The goal of the blog is to share facts from multiple sources, but also to get you to think hard about them.
? More Disclaimers here

Source: http://neurolove.me/post/51100969596

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Wednesday, May 22, 2013

Enzyme-activating antibodies revealed as marker for most severe form of rheumatoid arthritis

May 22, 2013 ? In a series of lab experiments designed to unravel the workings of a key enzyme widely considered a possible trigger of rheumatoid arthritis, researchers at Johns Hopkins have found that in the most severe cases of the disease, the immune system makes a unique subset of antibodies that have a disease-promoting role.

Reporting in the journal Science Translational Medicine online May 22, the Johns Hopkins team describes how it found the novel antibodies to peptidylarginine deiminase 4, or PAD4, in blood samples from people with aggressive inflammation and connective tissue damage.

Researchers say the presence of so-called PAD3/PAD4 cross-reactive autoantibodies could serve as the basis for the first antibody-specific diagnostic test to distinguish those with severe rheumatoid arthritis from those with less aggressive forms of the disease.

"Identifying early on a subset of patients with severe rheumatoid arthritis could benefit their health, as these patients could start aggressive drug therapy immediately and find the most effective treatment option," says senior study investigator Antony Rosen, M.D. Rosen, director of rheumatology and the Mary Betty Stevens Professor at the Johns Hopkins University School of Medicine, says that a third, or 1 million of the more than 3 million Americans -- mostly women -- estimated to have rheumatoid arthritis have an aggressive form of the disease.

In the study, the antibodies were present -- in 18 percent of 44 fluid samples from one research collection and in 12 percent of another collection of 194 -- but only in people with severe cases of rheumatoid arthritis. Past research shows that those with the most aggressive disease are less likely to respond to anti-inflammatory treatments with steroids and other drugs.

An examination of patients' medical records revealed that 80 percent of patients with the antibody saw their disease worsen over the previous year, while only 53 percent without the antibody showed disease progression. In comparing average scores of disease-damaged joints, researchers found that those with the antibody had an average deterioration in joints and bones by a score of 49. Those without the antibody had an average degradation in their score of 7.5, indicating much milder disease.

In a related finding, the Johns Hopkins team also uncovered how the PAD3/PAD4 cross-reactive auto-antibodies might contribute to more severe, erosive disease in rheumatoid arthritis. The team performed a series of experiments to gauge the antibodies' effects on PAD4 in response to varying cell levels of calcium, on which PAD enzymes depend.

Lab experiments showed that the antibodies greatly increase PAD4 enzyme function at the low levels of calcium normally present in human cells. Results showed that PAD4 activity was 500 times greater in the presence of antibodies than when they were absent. Tests of the antibody and enzymes' chemical structures later showed that the antibodies bind to PAD4 in the same region as calcium, suggesting to researchers that the antibodies might be substituting for calcium in activating the enzyme.

According to Rosen, the series of experiments, which took two years to complete, represents the first evidence of an antibody having a direct role in generating the targets of the immune response, or auto-antigens, in rheumatoid arthritis.

"Our results suggest that drugs inhibiting the PAD4 enzyme may have real benefit in patients with severe rheumatoid arthritis and represent an important field of study for investigating new and alternative treatments," says lead study investigator and biologist Erika Darrah, Ph.D.

Darrah says the team next plans long-term monitoring of arthritis sufferers to find out when the antibody first appears in the blood, and when intervention may have maximum impact in preventing or stalling disease progression. The team also plans further experiments to see if the antibody is taking control of the chemical pathways normally used by other cell proteins to control PAD4 sensitivity to calcium.

Funding support for this study was provided by the National Institutes of Health, and corresponding grant number T32-AR048522; the American College of Rheumatology; the Donald B. and Dorothy L. Stabler Foundation; and Sibley Memorial Hospital.

In addition to Rosen and Darrah, other Johns Hopkins researchers involved in this study were Jon Giles, M.D.; Michelle Ols, Ph.D.; and Felipe Andrade, M.D., Ph.D. Additional research assistance was provided by enzymologist Herbert Bull, Ph.D.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/JUMsJSIwPuo/130522141839.htm

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High court uphold FCC power in cell tower disputes

WASHINGTON (AP) ? The Supreme Court has affirmed the authority of federal regulators to try to speed local government decisions on proposals to build or expand cell phone towers.

The court voted 6-3 Monday to uphold an appeals court ruling in favor the Federal Communications Commission.

The case involves complaints to the FCC by telecommunications companies and the wireless industry that local authorities are delaying the placement and construction of wireless service facilities. The FCC said that local jurisdictions generally should act on applications within three months for existing structures and five months for new towers.

Several cities challenged the FCC's authority.

Justice Antonin Scalia, writing for the court, rejected the cities' claims.

Chief Justice John Roberts, joined by Justices Samuel Alito and Anthony Kennedy, dissented.

Source: http://news.yahoo.com/high-court-uphold-fcc-power-cell-tower-disputes-144027871.html

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